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Experimental Study of Bile Duct Reconstruction by Jejunal Interposition and by Roux-Y Jejunal Limb


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Title: Experimental Study of Bile Duct Reconstruction by Jejunal Interposition and by Roux-Y Jejunal Limb
Authors: Harada, Noboru
Issue Date: 14-Dec-1990
Citation: Acta medica Nagasakiensia. 1990, 35(1-4), p.228-236
Abstract: In studies to elucidate the mechanism of gastric acid hypersecretion after Roux-Y bille diversion, Heidenhain pouches were constructed in 19 healthy mongrel dogs. The construction of 40-cm blind ended Roux-Y jejunal limbs in 5 dogs caused significant increase in total 24-hour acid secretion, an average rise of 148 percent of the control levels. This increase was further augmented when bile flow was directed into the jejunum via these limbs. Similar significant acid increase occurred when the end of a 40-cm blind jejunal segment was anastomosed to the side of the duodenum in 6 dogs. Complete diversion of bile into the duodenum via the jejunal segment produced even greater acid output, an average of a 138 percent increase, although this was reversed to normal by shortening the jejunal segment. Primary construction of jejunal interpostiion choledochoduodenostomy in 4 dogs or choledochojejunostomy Roux-en-Y in 4 dogs also induced hypersecretion. Serum gastrin levels were not changed significantly throughout this study except when a 40-cm blind ended jejunal segment was inserted into the duodenum. Results of liver function tests remained unchanged.
URI: http://hdl.handle.net/10069/15847
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 35, No. 1-4

Citable URI : http://hdl.handle.net/10069/15847

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