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Evaluation of Prognosis for Borrmann IV Gastric Cancer In Terms of DNA Analysis and Nucleolus Number


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Title: Evaluation of Prognosis for Borrmann IV Gastric Cancer In Terms of DNA Analysis and Nucleolus Number
Authors: Chijiwa, Hideo
Issue Date: 14-Dec-1990
Citation: Acta medica Nagasakiensia. 1990, 35(1-4), p.241-249
Abstract: It is well known that Borrmann IV gastric cancer allows a most formidable prognosis. The influential factors on the prognosis of the 40 patients with Borrmann IV gastric cancer were evaluated by means of DNA analysis and nucleolus assessment of neoplastic cells obtained from embedded block of surgical specimens. The prognosis in patients with aneuploid pattern which account for 77.5% in this series was worse rather than that with diploid pattern on DNA histogram and also histologic findings of vascular invasion of ly (+), v (+) were mostly included into aneuploid pattern. It is assumed that the smaller the size of nucleolus in diameter, the higher the incidence of aneuploid pattern and the worse the prognosis of Borrmann IV gastric cancer has become. It is concluded that combination of DNA analysis with assessment of nucleolar number and size is required for detailed evaluation of the prognosis for Borrmann IV gastric cancer.
URI: http://hdl.handle.net/10069/15849
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 35, No. 1-4

Citable URI : http://hdl.handle.net/10069/15849

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