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Evaluation of SOD Activity in Gastric Cancer

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Title: Evaluation of SOD Activity in Gastric Cancer
Authors: Watabe, Seiichiro
Issue Date: 14-Dec-1990
Citation: Acta medica Nagasakiensia. 1990, 35(1-4), p.250-258
Abstract: For the purpose of clarifying the defensive capacity of the tumor-bearing host against the tumor was evaluated from the standpoint of superoxide dismutase (SOD) activity in the peripheral blood of untreated gastric cancer patients as compared with clinicopathologic factors. There was not significant difference in SOD activity between the entire gastric cancer patients and normal subjects. In contrast, a significant difference in SOD in monocytes (MNC) and polynuclear leucocytes (PMN) was found between early and advanced gastric cancer patients. SOD activities in advanced gastric cancer patients were obviously depressed. According to the disease stage, those in Stage IV patients were also apparently reduced when compared to reduction of superoxide dismutase (SOD) activity in MNC was observed in patients with hepatic metastasis (p<0.05) and that in MNC and PMN was seen in patients with peritoneal dissemination (p<0.01). As for gross findings by Borrmann' classification, Borrmann IV gastric cancer revealed significantly reduced SOD activity in MNC and PMN (p<0.01). It is concluded that SOD activity in the peripheral blood was depressed in accordance with advanding cancer stage. On the in vitro basic study to clarify the mechanism on SOD activity in gastric cancer patients it was certified that there was no influence of extracellular factors such as serum factor obtained from cancer-bearing patients, cultured cells, immunodepressant factor and nutrients on SOD activity. In contrast, intracellular factor of inhibitors of RNA and protein synthesis induced by adriamycin, actinomycin puromycin was greatly responsible for SOD activity in cultured cells. However, the inhibition of DNA synthesis could be not entirely neglected. It is dubious in association with inhibition of DNA synthesis. It was warned that the use of chemotherrapy of adriamycin and actinomycin D contributed to reduced SOD activity for the treatment of advanced cancers such as stage IV and Borrmann IV gastric cancers.
URI: http://hdl.handle.net/10069/15850
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 35, No. 1-4

Citable URI : http://hdl.handle.net/10069/15850

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