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Clinical Study on Plasma Fibronectin Level and Cellular Fibronectin Localization in Gastric Cancer


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Title: Clinical Study on Plasma Fibronectin Level and Cellular Fibronectin Localization in Gastric Cancer
Authors: Kawabuchi, Takayuki
Issue Date: 14-Dec-1990
Citation: Acta medica Nagasakiensia. 1990, 35(1-4), p.265-273
Abstract: Plasma fibronectin (pFN) in patients with gastric cancer was measured by ELISA method in the aspect of clinical significance. And also cellular fibronectin (cFN) was detected by means of immunochemical staining to clarify the localization of the basal membran and stroma. pFN was a significantly reduced in patients with gastric cancer and hepatocelllular carcinoma. In the postoperative course, a peak reduction was observed on day 1 and recovery was retarded in patients with gastric cancer. It was ascertained in this study that pFN indicated the patient's nutritional states and also reflected the function of the reticuloendothelial system. A few carcinomas showed discontinuous staining on the surface in some of papillary adenocarcinomas, well differentiated and moderately differentiated carcinomas and on the basement membrane of metastatic lymphnodes. It is certified that cFN localization correlated well with local invasion and node metastasis, and there was nothing to show cFN localization at the sites of deep invasion and involved lumen of lymph vessels.
URI: http://hdl.handle.net/10069/15852
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 35, No. 1-4

Citable URI : http://hdl.handle.net/10069/15852

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