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COLORECTAL CARCINOMA IN PATIENTS LESS THAN 40 YEARS OF AGE : PATHOLOGY AND PROGNOSIS


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Title: COLORECTAL CARCINOMA IN PATIENTS LESS THAN 40 YEARS OF AGE : PATHOLOGY AND PROGNOSIS
Authors: Shimoyama, Takatoshi / Ishikawa, Hiroshi / Kusano, Hiroyuki / Nakazaki, Takayuki / Uchikawa, Tetsuya / Yoshida, Ryuichiro / Shimi, Teruhisa / Nakagoe, Tohru / Hirano, Tatsuo / Miura, Toshio / Tomita, Masao
Issue Date: 25-Dec-1991
Citation: Acta medica Nagasakiensia. 1991, 36(1-4), p.6-11
Abstract: Clinicopathologic features in 35 patients below the age of 40 years with colorectal carcinoma were reviewed and compared with those of a control group containing 409 patients ranging from 40 to 74 years of age. All cases in this series were experienced at the First Department of Surgery, Nagasaki University School of Medicine, during the 18 years from 1970 to 1988. 1) Young patients accounted for 6.7% of all cases with colorectal cancer, and this group included more female patients than in the elderly control group. 2) The young patient group presented with advanced lesions (Dukes' stage C) in 54.3% of cases compared with 35.6% of the old patient group with significantly high incidences of lymph node involvement. There were no significant differences in the hepatic metastasis and peritoneal dissemination among two groups. 3) Mucinous carcinoma and vascular invasion were frequently found on histologic examination in the young group, which suggested the highly malignant potentiality, but no significant difference in DNA ploidy pattern was observed between the young and the control group. 4) Curative resection rates were 71.4% in young and 68.1% in elderly patients. Overall 5-year survival was 56.9%. Five-year survival in 25 patients undergoing potentially curative resection increased to 74.4% with the similar rates of the control group. Improved 5-year survival following potentially curative resection stresses the need for early diagnosis and treatment.
URI: http://hdl.handle.net/10069/15857
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 36, No. 1-4

Citable URI : http://hdl.handle.net/10069/15857

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