DSpace university logo mark
詳細検索
Japanese | English 

NAOSITE : Nagasaki University's Academic Output SITE > 030 医学部 > 030 紀要 > Acta Medica Nagasakiensia > Volume 36, No. 1-4 >

Induction of Killer Activity in Peripheral Blood Mononuclear Cells after Chemotherapy with Methotrexate, Vinblastine, Adriamycine and Cis-platin (M-VAC)


ファイル 記述 サイズフォーマット
acta36_01_07_t.pdf351.32 kBAdobe PDF本文ファイル

タイトル: Induction of Killer Activity in Peripheral Blood Mononuclear Cells after Chemotherapy with Methotrexate, Vinblastine, Adriamycine and Cis-platin (M-VAC)
著者: Taniguchi, Keisuke
発行日: 1991年12月25日
引用: Acta medica Nagasakiensia. 1991, 36(1-4), p.29-33
抄録: We have studied NK activity against K562 cells and killer activity against NK-resistant Raji cells after administration of Methotrexate. Vinblastine, Adriamycine and Cis-platin (M-VAC) in patients with transitional cell carcinoma and found the appearance of strong lytic activity against K562 cells and Raji cells (lymphokine activated killer(LAK)-like activity) appeared 24.3 ± 6.5 days after the administration of first cycle of M-VAC and the lytic unit (LU) was 418.4 ± 177.4 (LU of pre-chemotherapy: 88.6 ± 61.2). NK activity against K562 cells showed the same course as lymphokinne activated killer-like activity. There was a significant difference in activity of NK cells and LAK-like cells between pre-chemotherapy and maximum. NK cells and LAK-like cells activities after second or third cycle of M-VAC showed the same course as those of first cycle of M-CAC. Lymphocyte count decreased temporarily and increased during maximal activities of NK cells and LAK-like cells in each cycle of M-VAC therapy. However, maximal peak of lymphocyte count delayed in comparison with that of maximal activities of NK cells and LAK-like cells. Lymphokines, such as IL-2 may play a role to generate these enhanced NK activity and LAK-like activity. The data presented in this report suggests that the nature, dose, and timing of chemotherapeutic agent should be considered from the point of immunological mechanism.
URI: http://hdl.handle.net/10069/15862
ISSN: 00016055
資料タイプ: Departmental Bulletin Paper
原稿種類: publisher
出現コレクション:Volume 36, No. 1-4

引用URI : http://hdl.handle.net/10069/15862

このリポジトリに保管されている文献はすべて著作権により保護されています。
印刷やダウンロード等データの複製は、調査研究・教育または学習を目的とする場合に限定されます。

 

Valid XHTML 1.0! Copyright © 2006-2015 長崎大学附属図書館 - お問い合わせ Powerd by DSpace