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Induction of Killer Activity in Peripheral Blood Mononuclear Cells after Chemotherapy with Methotrexate, Vinblastine, Adriamycine and Cis-platin (M-VAC)


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Title: Induction of Killer Activity in Peripheral Blood Mononuclear Cells after Chemotherapy with Methotrexate, Vinblastine, Adriamycine and Cis-platin (M-VAC)
Authors: Taniguchi, Keisuke
Issue Date: 25-Dec-1991
Citation: Acta medica Nagasakiensia. 1991, 36(1-4), p.29-33
Abstract: We have studied NK activity against K562 cells and killer activity against NK-resistant Raji cells after administration of Methotrexate. Vinblastine, Adriamycine and Cis-platin (M-VAC) in patients with transitional cell carcinoma and found the appearance of strong lytic activity against K562 cells and Raji cells (lymphokine activated killer(LAK)-like activity) appeared 24.3 ± 6.5 days after the administration of first cycle of M-VAC and the lytic unit (LU) was 418.4 ± 177.4 (LU of pre-chemotherapy: 88.6 ± 61.2). NK activity against K562 cells showed the same course as lymphokinne activated killer-like activity. There was a significant difference in activity of NK cells and LAK-like cells between pre-chemotherapy and maximum. NK cells and LAK-like cells activities after second or third cycle of M-VAC showed the same course as those of first cycle of M-CAC. Lymphocyte count decreased temporarily and increased during maximal activities of NK cells and LAK-like cells in each cycle of M-VAC therapy. However, maximal peak of lymphocyte count delayed in comparison with that of maximal activities of NK cells and LAK-like cells. Lymphokines, such as IL-2 may play a role to generate these enhanced NK activity and LAK-like activity. The data presented in this report suggests that the nature, dose, and timing of chemotherapeutic agent should be considered from the point of immunological mechanism.
URI: http://hdl.handle.net/10069/15862
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 36, No. 1-4

Citable URI : http://hdl.handle.net/10069/15862

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