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The Effect of Epidermal Growth Factor, Basic Fibroblast Growth Factor, Transforming Growth Factor-β, and Insulin on the DNA Synthesis of Renal Cell Carcinoma Cell Lines.


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Title: The Effect of Epidermal Growth Factor, Basic Fibroblast Growth Factor, Transforming Growth Factor-β, and Insulin on the DNA Synthesis of Renal Cell Carcinoma Cell Lines.
Authors: Nishimura, Naoki
Issue Date: 25-Dec-1991
Citation: Acta medica Nagasakiensia. 1991, 36(1-4), p.47-51
Abstract: In this experiment, the effect of various growth factors (epidermal growth factor, basic fibroblast growth factor, transforming growth factor-β and insulin) on the DNA synthesis of three renal cell carcinoma cell lines (ACHN, VMRC-RCW, NT) has been investigated in a serum free condition. These growth factors atimulated the DNA synthesis of all renal cell carcinoma cell lines dose-dependently. Transforming growth factor-β, a known growth inhibitor for renal tubular cells, stimulated the DNA synthesis of renal cell carcinoma cells. The conditioned medium (which did not include any serum) contained very litle autocrine growth factor for renal cell carcinoma cell itself. These results suggest that paracrine growth factors are mostly related to the growth of renal cell carcinoma cells than autocrine growth factor. The renal cell carcinoma cells, which are the transformed form of renal tubular cells and due to this transformed character, TGF-β which is basically a growth inhibitor for tubular cell but stimulates the renal cell carcinoma cell.
URI: http://hdl.handle.net/10069/15866
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 36, No. 1-4

Citable URI : http://hdl.handle.net/10069/15866

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