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Effect of 1-arginine HC1 and OK-432 on the inhibition of Lung Metastasis in Mice


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Title: Effect of 1-arginine HC1 and OK-432 on the inhibition of Lung Metastasis in Mice
Authors: Mine, Yoshikazu
Issue Date: 25-Dec-1991
Citation: Acta medica Nagasakiensia. 1991, 36(1-4), p.128-135
Abstract: To investigate the effect of OK-432 and 1-arginine HC1 on the artificial metastases in lung, mice were injected mouse colon carcinoma, colon 26 cells(1×10 6). Pulmonary nodules produced by the i. v. injection of 1×10 6 colon tumor 26 cells into a caudal vein were evaluated after 3 weeks. OK-432, 1KE/mouse, was administered by the i. v. injection three times on day 0, 2, 4 after the tumor injection. L-arginine HC1, 50mg/mouse, was given by the i. p. injection 6-7 times on day 0, 1, 2,3,4,5,6. IV administration of OK-432 led to a significant suppression of lung metastases formation in comparison to salin-injected animals. Furthermore, OK-432 and i. p. administration of 1-arginine HC1 let to a considerable, synergisticaly retardation of tumor metastasis. The suppressive effect of OK-432 and 1-arginine HC1 on the artificial lung metastases may be due to its activation of the immunologic system. And this work suggest that OK-432 and 1-arginine HC1 enhanced the phagocytic activity of macrophages in vivo.
URI: http://hdl.handle.net/10069/15879
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 36, No. 1-4

Citable URI : http://hdl.handle.net/10069/15879

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