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Lectin Immunohistochemistry in Human Non-Malignant and Malignant Gallbladder Tissuses

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Title: Lectin Immunohistochemistry in Human Non-Malignant and Malignant Gallbladder Tissuses
Authors: Muazzam, Faisal / Toda, Takayoshi / Tomita, Shuji / Deguchi, Shigeru / Muto, Yoshihiro / Ono, Iwao
Issue Date: 25-Dec-1991
Citation: Acta medica Nagasakiensia. 1991, 36(1-4), p.176-184
Abstract: Changes in the lectin binding pattern in non-malignant and malignant gallbladder tissues were examined using the following eight types of carbohydrate binding lectins : Ulex europaeus-1 (UEA-1), Arachis hypogaea (PNA), Griffonia simplicifolia (GS-1), Glycine maximum (SBA), Bauhinia purpurea (BPA), Dolichos biflorus (DBA), Canavalia ensiformis (Con-A), and Triticum vulgare (WGA). We used a total of 109 tissues including 31 normal tissues, 25 metaplasias, and 53 carcinomas. Lectin staining pattern was evaluated using the Hamada's crieria of the following four types : apical type, cytoplasmic type with polarity, cytoplasmic type without polarity, and stromal type. Normal cases showed apical type and cytoplasmic type with polarity, while carcinoma cases revealed cytoplasmic type with or without polarity. In carcinoma cases, GS-I and DBA lectins showed higher immunohistochemical positive rate and more frequent cytoplasmic type with polarity pattern of immunohistochemical localization than the other types of lectins. These results suggest that the GS-I and DBA are the most reliable lectin marker for malignant transformation of the gallbladder tissues. Key words : Lectin, immunohistochemistry, gallbladder carcinoma.
URI: http://hdl.handle.net/10069/15887
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 36, No. 1-4

Citable URI : http://hdl.handle.net/10069/15887

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