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Experimental Study on Reperfusion Injury to Warm Ischemic Lung Protective effect of CV-3611 and α-tocopherol on reperfusion lung-


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Title: Experimental Study on Reperfusion Injury to Warm Ischemic Lung Protective effect of CV-3611 and α-tocopherol on reperfusion lung-
Authors: Hisano, Hiroshi
Issue Date: 25-Dec-1991
Citation: Acta medica Nagasakiensia. 1991, 36(1-4), p.243-251
Abstract: In the experiment of a donor lung with a three hour warm ischemia the effects of antioxidant drugs, CV-3611 and α-tocopherol, on reperfusion injury were evaluated on dogs with left lung transplantation. 1)CV-3611 and α-tocopherol are of great benefit to prevent a donor lung from reperfusion injury, remaining satisfactory alveolar ventilation. 2)The addition of CV-3611 and α-tocopherol was depressed enough to generate the volume of lipid peroxidase in the lung tissues. 3) The pulmonary vascular resistance increased without exception in all groups, demonstrating no effect of antioxidant drugs. 4)The statistic compliance was remained satisfactory by α-tocopherol. 5) There was a tendency toward a decrease in oxidative product in neutrophils by CV-3611. This results suggest that CV-3611 and α-tocopherol should be of great use to avoid occurring reperfusion injury to ischemic lungs.
URI: http://hdl.handle.net/10069/15898
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 36, No. 1-4

Citable URI : http://hdl.handle.net/10069/15898

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