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Association of the Hepatic Expression of β2-Microglobulin with Spontaneous Hepatitis Be Antigen Seroconversion in Chronic Hepatitis B


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Title: Association of the Hepatic Expression of β2-Microglobulin with Spontaneous Hepatitis Be Antigen Seroconversion in Chronic Hepatitis B
Authors: Kinoshita, Noboru
Issue Date: 25-Dec-1993
Citation: Acta medica Nagasakiensia. 1993, 38(2-4), p.95-99
Abstract: Hepatic expression of hepatitis B core antigen(HBcAg)and β2- mi croglobulin (β2-MG) was studied in 42 patients with liver biopsy-proven chronic hepatitis B; 31 were hepatitis Be antigen (HBeAg)-seropositive and 11 were anti-HBeAg antibody (anti- HBe)-seropositive at base line. The degrees of expression of both HBcAg and β2-MG at base line were significantly higher in HBeAgseropositive patients than in anti-HBe-seropositive patients (p < 0.001 and p < 0.001, respectively). During two-year-follow-up, 14 of 31 HBeAg-seropositive patients were seroconverted to anti-HBe (HBe-seroconversion). When the base line hepatic expression of HBcAg and β2-MG was compared between the patients with subsequent HBe-seroconversion and the non-soroconverted patients, β2-MG expression on hepatocytes in the patients with subsequent HBe-seroconversion was significantly more intense than that in the non-soroconverted patients (p < 0.025). In contrast, the degrees of HBcAg expression at base line were not different between the two groups. These results suggest that the hepatic expression of β2-MG as well as that of HBcAg correlates with the serum level of HBeAg and that the increased expression of β2-MG is followed by HBe-seroconversion in patients with chronic hepatitis B.
Keywords: croglobulin / HBcAg / chronic hepatitisB
URI: http://hdl.handle.net/10069/15916
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 38, No. 2-4

Citable URI : http://hdl.handle.net/10069/15916

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