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Clinical Significance of Serum Prealbumin Concentration in Patients with Liver Cirrhosis


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Title: Clinical Significance of Serum Prealbumin Concentration in Patients with Liver Cirrhosis
Authors: Tajima, Heiichiro
Issue Date: 25-Dec-1993
Citation: Acta medica Nagasakiensia. 1993, 38(2-4), p.100-102
Abstract: Prealbumin is a very rapid turnover protein produced by hepatocytes. We studied the association of serum prealbumin concentration with prognosis in 55 patients with liver cirrhosis. These included 28 men and 27 women, aged 46 to 70 years old (mean ± SD: 55.9 ± 10.8 years old). The clinical stages of these 55 patients at base line were classified according to the Pugh's scoring system; 39 were in stage A, 12 in stage B and 4 in stage C. During follow-up, 3 of 12 stage B patients as well as all of the four stage C patients died from hepatic failure, whereas none of 39 stage A patients died. When the prognostic factors were analyzed in 16 patients with stage B or C, the base line serum prealbumin concentration was significantly lower in 7 died patients than in 9 alive patients (P < 0.05); in contrast, the serum bilirubin level, the serum albumin concentration or prothrombin time at base line were not different between the two groups (P > 0.05, P > 0.1 and P > 0.4, respectively). These results suggest that the serum prealbumin concentration can be used clinically as a prognostic marker in patients with liver cirrhosis.
URI: http://hdl.handle.net/10069/15917
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 38, No. 2-4

Citable URI : http://hdl.handle.net/10069/15917

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