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Changes of Concentrations of Free Amino Acids in HeLa Cells Induced by Antitumor Agent


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Title: Changes of Concentrations of Free Amino Acids in HeLa Cells Induced by Antitumor Agent
Authors: Tagawa, Yutaka / Mine, Yoshikazu / Yasutake, Toru / Matsuo, Satoshi / Tomita, Masao
Issue Date: 25-Dec-1993
Citation: Acta medica Nagasakiensia. 1993, 38(2-4), p.265-269
Abstract: In this report we have investigated that the amino acid is most actively metabolized in the tumor cells damaged by antitumor agents, and discussed imbalanced amino acid procedure to be combined with cancer chemotherapy. The concentrations of 24 free amino acids in medium and in cells were determined in HeLa cells treated with Adriamycin. The free amino acids that decreased in the medium but increased in cells were glutamine and arginine. From this result, we treated HeLa cells with Adriamycin in medium of glutamine-deficiency and obtained a marked cytocidal effect. It would be difficult to make tumor tissues of glutamine-depletion in the whole body. For clinical application, local administration such as intraarterial infusion of L-glutamine antagonists combined with antitumor agents is expected as a practical administration method.
Keywords: Glutamine / Free amino acid / Adriamycin / Amino acid imbalance
URI: http://hdl.handle.net/10069/15952
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 38, No. 2-4

Citable URI : http://hdl.handle.net/10069/15952

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