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DNA Analysis from Biopsied Specimens for Carcinomas of the Esophagus


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Title: DNA Analysis from Biopsied Specimens for Carcinomas of the Esophagus
Authors: Tomita, Masao / Hara, Shinsuke / Tagawa, Yutaka / Kawahara, Katsunobu / Ayabe, Hiroyoshi / Obatake, Masayuki / Sawai, Terumitsu / Jibiki, Masaaki / Morinaga, Masafumi / Matsuo, Toshikazu / Matsuo, Satoshi / Yoshida, Akira / Furukawa, Taizou / Yoshida, Ryuichiro / Eguchi, Masaaki / Takahashi, Takao / Sakai, Tsutomu / Okada, Daikichi / Makiyama, Takao
Issue Date: 25-Dec-1993
Citation: Acta medica Nagasakiensia. 1993, 38(2-4), p.270-272
Abstract: Surgical outcome for advanced esophageal cancer patients is not satisfactory in spite of improvements of diagnostic tools, operative techniques, postoperative cares and adjuvant chemotherapy. Postoperative prognosis used to be predicted by the grades of histologic disease progression. However, it is limited to accurate prediction of its prognosis. Recent studies have been focused on biologic behavior of malignant cells, in particular, nuclear DNA contents which play an important role in cell proliferation and metabolizm. Clinical use of flow-cytometric measurement of nuclear DNA is now prevalent to assess the grades of malignancy for malignant tumors. In contrast, it is difficult to know nuclear DNA contents preoperatively. The purpose of this study is to clarify whether or not preoperative biologic behaviors is clinically feasible, from biopsied specimens in comparison with that from the surgical specimens.
URI: http://hdl.handle.net/10069/15953
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 38, No. 2-4

Citable URI : http://hdl.handle.net/10069/15953

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