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In Vivo and in Vitro Activation of Lymphocytes by IFN-α and IFN-γ in Patients with Renal Cell Carcinoma


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Title: In Vivo and in Vitro Activation of Lymphocytes by IFN-α and IFN-γ in Patients with Renal Cell Carcinoma
Authors: Sakaguchi, Miki
Issue Date: 25-Oct-1994
Citation: Acta medica Nagasakiensia. 1994, 39(1-3), p.34-38
Abstract: Treatment with interferon (IFN) for renal cell carcinoma was started in 1982 as one of the immunotherapies, but it is not so effective and no definite way of administration has been established yet. In thie report for the purpose of studying the action mechanism of IFN-α and IFN-γ, cytotoxic activity of peripheral blood mononuclear cells (PBMNCs) of the patients with renal cell carcinoma. When the patients' PBMNCs were treated with IFNs at various concentrations, difference was noted in each patient referring to IFNs and their concentrations for obtaining the maximum LAK-like activity using ACHN derived from human renal cell carcinoma as target cells. Further, the combined effect of cytotoxicity obtained by IFN-α and IFN- γ at their optimal concentration was additive in comparison with LAK-like activities upon therapy with IFN-α or IFN- γ alone respectivly. Further, when the action mechanism of IFN-γ was studied referring to subpopulation of the normal donor'PBMNCs by cell sorting, the strong LAK-like activity was induced on the lymphocyte fraction CD3(+)CD4(-). Further in consideration of cytokine concentrations measured and the above results, it seems that IFN-γ acts directly on the lymphocyte fraction CD3(+) CD4(-) to induce the LAK-like activity.
URI: http://hdl.handle.net/10069/15968
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 39, No. 1-3

Citable URI : http://hdl.handle.net/10069/15968

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