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Effects of FK506 on the Growth of Freshly lsolated Parenchymal Hepatocytes and Renal Cortical Tubular Cells


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Title: Effects of FK506 on the Growth of Freshly lsolated Parenchymal Hepatocytes and Renal Cortical Tubular Cells
Authors: Kawamura, Masaya
Issue Date: 25-Oct-1994
Citation: Acta medica Nagasakiensia. 1994, 39(1-3), p.45-49
Abstract: FK506 is a immunosuppressive agent used in kidney and liver transplantation. After transplantation, kidney or liver usually starts hyperplasia or regeneration supported by cellular growth. The effects of FK506 on the growth of freshly isolated rat parenchymal hepatocytes or rabbit renal cortical tubular cells in culture were examined within a concentration range of 10μM. FK506 inhibited the DNA synthesis of cultured hepatocytes and renal tubular cells in a dosedependent manner. This was not due to increase of release of the activated transforming growth factor一β.The Cytotoxic effect of FK506 on the cells was examined, but no significant increase in the release of N-acetyl一β,D-glucosaminidase (NAG) from tubular cells or of glutamic oxaloacetic transaminase (GOT) from hepatocytes was observed. FK506 at a non-cytotoxic concentration thus appears to directly inhibit the growth of cultured hepatocytes and tubular cells in vitro.
URI: http://hdl.handle.net/10069/15971
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 39, No. 1-3

Citable URI : http://hdl.handle.net/10069/15971

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