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A Study of the Correlation Between Cell Proliferation Capacity and Numerical Chromosomal Aberrations in Colon Cancer


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Title: A Study of the Correlation Between Cell Proliferation Capacity and Numerical Chromosomal Aberrations in Colon Cancer
Authors: Akama, Fumitaka
Issue Date: 25-Oct-1994
Citation: Acta medica Nagasakiensia. 1994, 39(1-3), p.54-58
Abstract: We conducted a study of the correlation between numerical chromosomal aberrations and cell proliferation capacity in colon cancer using FISH, PCNA, Ki-67, DNA polymerase α, and DNA ploidy. The LI of Ki-67 and DNA polymerase a did not show a correlation with any pathological factors. However, the PCNA LI showed a correlation with mitotic index, and a correlation was also observed between venous invasive factors and lymphatic invaseve factors. A high level of the PCNA LI therefore thought to indicate a high degree of melignancy, thus requiring extremely close follow-up. Among chromosomes No. 7, 11, and 17, a correlation was observed between numerical aberrations in chromosome 17 and the PCNA Ll.
URI: http://hdl.handle.net/10069/15973
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 39, No. 1-3

Citable URI : http://hdl.handle.net/10069/15973

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