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Efficacy of 15-deoxyspergualin in Canine Lung Transplantation


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Title: Efficacy of 15-deoxyspergualin in Canine Lung Transplantation
Authors: Nakamura, Akihiro
Issue Date: 25-Oct-1994
Citation: Acta medica Nagasakiensia. 1994, 39(1-3), p.87-93
Abstract: Deoxyspergualin (DSG) is a new immunosuppressive agent derived from the bacterium Bacillus laterosporus. In this study, we evaluated the immunosuppressive efficacy of DSG in cases of canine lung allotransplantation and the influence of DSG on bronchial anastomotic healing. Twentyfour adult mongrel dogs underwent left lung transplantation. The animals were classified into four groups. Group 1 (n = 4) dogs received DSG dosage of 4.8 to 1.2 mg/kg/day. Group 2 (n = 7) dogs received DSG dosage of 0.8 mg/kg/day. Group 3 (n = 6) dogs were administered a combination therapy consisting of 0.5 mg/kg/day and 10 mg/kg/day of DSG and cyclosporin A (CsA), respectively. Group 4 (n = 7) dogs served as controls, receiving 10 mg/kg/day of CsA. Acute rejection was almost completely suppressed in Group 1 dogs, but severe toxic side effects including emaciation, diarrhea, and pulmonary congestion were often observed. In the grafted lungs of Group 2 dogs, minimal rejection occurred, but improved within three weeks after surgery. A mononuclear cell infiltration characteristically appeared around the bronchus rather than around the vessels. Grafted lung rejection was suppressed sufficiently in Group 3 dogs. However, multiple lung abscesses were found in both the grafted and native lungs of these dogs. Pseudomonas aeruginosa was isolated in a bacterial culture study. Side effects such as gastrointestinal disturbances were mild. The bronchial mucosal blood flow in recipient dogs was measured by a laser Doppler velocimetry. The blood flow did not decrease markedly in the dogs of Groups 2 and 4. In contrast, the blood flow of dogs in Groups 1 and 3 was significantly reduced. These data suggest that DSG is an effective immunosuppressive agent in canine lung allotransplantation. However, the DSG dosages for clinical use will require further study. This is especially true for cases of single use or when DSG is used in combination therapy.
URI: http://hdl.handle.net/10069/15978
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 39, No. 1-3

Citable URI : http://hdl.handle.net/10069/15978

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