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The Optimum Colloid Osmotic Pressure for Lung Preservation -A hyperoncotic solution which contains a high concentration of hydroxyethyl starch (HES) prevents pulmonary edema during preservation and reperfusion periods in hypothermic canine lung preservation -


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Title: The Optimum Colloid Osmotic Pressure for Lung Preservation -A hyperoncotic solution which contains a high concentration of hydroxyethyl starch (HES) prevents pulmonary edema during preservation and reperfusion periods in hypothermic canine lung preservation -
Authors: Muraoka, Masashi
Issue Date: 25-Oct-1994
Citation: Acta medica Nagasakiensia. 1994, 39(1-3), p.94-99
Abstract: The optimum hydroxyethyl starch (HES) concentration and colloid osmotic (oncotic) pressure were determined for lung preservation. The lungs of twenty-five mongrel dogs were isolated and flushed with one of four different solutions and stored at 4-6 °C for 24 hours. The lungs of each group were flushed and cold-stored as follows: Group 1 with Modified- Collins (CM) solution (n=6); Group 2, CM + 3 % HES (n=6); Group 3, CM +6 % HES (n=8); Group 4, CM + 9 % HES (n=5). After the hypothermic period, the isolated left lung was reperfused for 120 min. During reperfusion, the airway pressure (AWP) in Group 4 was significantly lower than in Groups 1 or 3. Static lung compliance (Cst) in Groups 2 and 4 was apparently higher than that in Group 1. Pulmonary vascular resistance (PVR) in Group 4 was significantly lower than in Group 1 throughout the reperfusion period. The wet to dry ratios (W/D) before perfusion in Group 1 (6.52±0.55) and in Group 2 (6.05±0.74) were significantly higher than before preservation (5.19±0.21). The W/Ds after reperfusion in Group 3 (6.82±0.78) and Group 4 (7.04±1.22) were significantly lower than that in Group 1 (9.40±2.09). In conclusion, a hyperoncotic solution which contains a high concentration of HES is useful for hypothermic canine lung preservation because it prevents pulmonary edema during both preservation and reperfusion periods.
URI: http://hdl.handle.net/10069/15979
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 39, No. 1-3

Citable URI : http://hdl.handle.net/10069/15979

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