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Study of Nuclear DNA Content and Chromosomal Numerical Aberrations Using Fluorescence in situ Hybridization in Colorectal Polyps and Colorectal Adenomas


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Title: Study of Nuclear DNA Content and Chromosomal Numerical Aberrations Using Fluorescence in situ Hybridization in Colorectal Polyps and Colorectal Adenomas
Authors: Jibiki, Masaaki
Issue Date: 25-Oct-1994
Citation: Acta medica Nagasakiensia. 1994, 39(1-3), p.100-105
Abstract: In this study, nuclear DNA content were compared with chromosomal numerical aberration by Fluorescence in situ Hybridization method in 41 cases of colorectal carcinomas and 12 cases of colorectal adenomas. In the adenomas, DNA aneuploidy was shown in 8.3%, and moreover, monosomy of the chromosome 11 was shown in 10% and trisomy of the chromosome 7 was shown in 28.6%. However, no abnormality in the chromosome 17 was defined. In contrast, with regard to the colorectal carcinomas, DNA aneuploidy was shown in 43.9%. Furthermore, it was observed that the rate of appearance of the chromosomal numerical aberrations was high. In the chromosome 17, the rate of appearance of trisomy was significantly higher in DNA aneuploidy cases as compared with DNA diploidy one. However, there was no significant difference in the chromosome 7 and the chromosome 11. In addition, with regard to the colorectal carcinomas in which the chromosome 17 was disomy, there were significantly a large number of cases with positive v factor, and in trisomy cases, there were a lot of cases with negative v factor. In conclusion, it is conceivable that detection of abnormality in chromosomes by FISH method provides a new index of the prognosis and the grade of malignancy in the colorectal carcinomas.
URI: http://hdl.handle.net/10069/15980
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 39, No. 1-3

Citable URI : http://hdl.handle.net/10069/15980

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