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Significance of AgNORs Ratio as a Prognostic Factor of Breast Cancer


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Title: Significance of AgNORs Ratio as a Prognostic Factor of Breast Cancer
Authors: Hatano, Kazuhiko
Issue Date: 25-Oct-1994
Citation: Acta medica Nagasakiensia. 1994, 39(1-3), p.179-183
Abstract: The numbers and the sizes of Argyrophilic Nucleolar Organizer Regions (AgNORs) were analysed in 76 cases of mammary invasive ductal carcinoma for the evaluation of biologic behaviour of breast cancer. For the measurement of AgNORs size, a total of AgNORs area per nucleus and the ratio of AgNORs area to the nuclear area were measured by automatic image analyzer as "AgNORs area" and "AgNORs ratio", respectively. Concerning the tumor grade, the mean AgNORs area and ratio were significantly increased in high grade tumor (area: p<0.001, ratio: p < 0.05). A significant increase (p<0.05) of the mean AgNORs ratio was shown in patients with nodal metastasis. The survival time was analysed among four groups separated according to the lymph node status and the mean value of AgNORs amounts. As a result in patients with nodal metastasis, the group that showed high AgNORs ratios of more than the mean value had significantly (p<0.05) shorter survival time as compared with the group of less than the mean AgNORs ratio. There was a tendency in the group of larger AgNORs areas toward poorer prognosis than that of smaller AgNORs areas. On the contrary, the AgNORs number was of no value to predict the prognosis. In the patients without nodal metastasis, the survival time was not affected by any of the AgNORs parameters. In conclusion, the AgNORs ratio was disclosed to be an important variable in predicting the prognosis of the patients with lymph node metastasis of breast cancer.
URI: http://hdl.handle.net/10069/15998
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 39, No. 1-3

Citable URI : http://hdl.handle.net/10069/15998

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