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The relationship between p53, c-myc product expression and clinicopathological parameters in primary breast carcinomas


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Title: The relationship between p53, c-myc product expression and clinicopathological parameters in primary breast carcinomas
Authors: Uchikawa, Tetsuya
Issue Date: 25-Oct-1994
Citation: Acta medica Nagasakiensia. 1994, 39(1-3), p.198-203
Abstract: Sixty-four primary breast carcinomas were analyzed by flow cytometry for their expression of p53 and c-myc proteins. c-myc protein expression was correlated with pathological infiltration (p = 0.05), but the other parameters (tumor size, lymph node status, menopausal status, steroid receptor status, and histological type) were not statistically correlated. On the other side, p53 protein expression was significantly correlated with large tumor size (p = 0.0001) and lymph node metastasis positive (p = 0.001), and weakly correlated with post menopausal status (p <0.01) and pathological infiltration (p = 0.01). Although there was no correlation between only p53 protein oevr-expression and disease free survival. but when p53 protein over-expression and c-myc protein oevr-expression were simultaneously found in the same tumor-cell population, prognosis of these cases were poor. Namely simultaneous over-expression of p53 protein and c-myc protein was found in 22 cases, 7 of 22 (31.8%) have had a relapse. In other 2 cases relapse was found, but both these cases were medullary carcinoma and the level of expression of p53, and c-myc protein was low. This study indicates that plural gene product expression should be simultaneously analyzed when investigate the prognostic markers in breast carcinomas.
URI: http://hdl.handle.net/10069/16002
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 39, No. 1-3

Citable URI : http://hdl.handle.net/10069/16002

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