DSpace university logo mark
Advanced Search
Japanese | English 

NAOSITE : Nagasaki University's Academic Output SITE > School of Medicine > Bulletin > Acta Medica Nagasakiensia > Volume 39, No. 4 >

Experimental-Induced Colitis in Rats by Ethanolic Solution of Trinitrobenzene Sulfonic Acid and Ethanol Alone : A Comparative Study


File Description SizeFormat
acta39_04_01_t.pdf2.46 MBAdobe PDFView/Open

Title: Experimental-Induced Colitis in Rats by Ethanolic Solution of Trinitrobenzene Sulfonic Acid and Ethanol Alone : A Comparative Study
Authors: Zea-Iriarte, Walter / Makiyama, Kazuya / Itsuno, Minoru / Umene, Yoshihiko / Hara, Kohei
Issue Date: 15-Dec-1994
Citation: Acta medica Nagasakiensia. 1994, 39(4), p.1-10
Abstract: Epidemiological data suggest an increase in both developed and undeveloped countries of inflammatory bowel disease. Furthermore, its etiology and pathophysiology remain unknown. Appropriated animal models are needed. We have studied a rat model of hapten-induced chronic colitis. In Wistar rats, intracolonic instillation of 20 mg or 42 mg of the hapten trinitrobenzene sulfonic acid in 30 % and 40 % ethanol proved to induce chronic colitis after 14 to 21 days of administration, in dose-dependent fashion when compared with ethanol alone that induced only acute colitis after three days of administration. This chronic colitis shares some characteristics with inflammatory bowel disease in humans, specially with Crohn's disease, such as transmural inflammation, development of strictures, ulcerations and infiltration of inflammatory cells throughout the colonic wall. These features make this model suitable for further studies of intestinal inflammation.
URI: http://hdl.handle.net/10069/16003
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 39, No. 4

Citable URI : http://hdl.handle.net/10069/16003

All items in NAOSITE are protected by copyright, with all rights reserved.

 

Valid XHTML 1.0! Copyright © 2006-2015 Nagasaki University Library - Feedback Powerd by DSpace