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Eosinophil Activation in Ulcerative Colitis


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Title: Eosinophil Activation in Ulcerative Colitis
Authors: Kanzaki, Shinichiro / Makiyama, Kazuya / Itsuno, Minoru / Yamasaki, Yoshiyuki / Oda, Hidetoshi
Issue Date: 15-Dec-1994
Citation: Acta medica Nagasakiensia. 1994, 39(4), p.40-44
Abstract: To evaluate the activity level of eosinophils in patients with ulcerative colitis (UC), we analyzed peripheral blood eosinophil counts, serum levels of eosinophil cationic protein (ECP) and the percentage of hypodense eosinophils among all eosinophils in peripheral blood. Patients with active UC had significantly higher serum ECP levels and eosinophil counts, compared with patients in remission and healthy controls. Serum ECP levels correlated positively with eosinophil counts. In patients who could be followed from the active stage of UC to remission, ECP decreased significantly over time and eventually reached approximately normal levels, while eosinophil counts showed no significant change. The mean percentage of hypodense eosinophils (specific gravity < 1.082 g/ml) in peripheral blood was 5% or less in patients in remission and healthy controls, but it was 31.7 % in patients with active UC. These results suggest that eosinophils are activated in patients with UC, and that they are involved in injury to the colorectal mucosa by inducing the release of cytotoxic proteins such as ECP.
Keywords: ulcerative colitis / eosinophil cationic protein / hypodense eosinophi
URI: http://hdl.handle.net/10069/16009
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 39, No. 4

Citable URI : http://hdl.handle.net/10069/16009

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