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A Study of Fine Yellowish-White Plaques in Mucosa of Ulcerative Colitis Using Immunoperoxidase Staining: A Comparison with Reddish Lesions


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Title: A Study of Fine Yellowish-White Plaques in Mucosa of Ulcerative Colitis Using Immunoperoxidase Staining: A Comparison with Reddish Lesions
Authors: Yamasaki, Yoshiyuki / Oda, Hidetoshi / Nakamuta, Kohji / Tomonaga, Michio / Kanzaki, Shin-Ichiro
Issue Date: 15-Dec-1994
Citation: Acta medica Nagasakiensia. 1994, 39(4), p.45-49
Abstract: Fine yellowish-white plaques(YWP), which are seen in the bowel mucosa of patients with ulcerative colitis (UC), are minute erosive lesions where infiltration of inflammatory cells are histologically observed. These lesions are thought to constitute the minimum unit of inflammation. To clarify the factors that determine the activity level of UC, we biopsied YWP, which persisted in the inactive stage of the disease, as well as reddish inflamed lesions(RL) in the active stage of the disease, and performed immunoperoxidase staining of intraepithelial cells and lamina propria mononuclear cells by using monoclonal antibodies against various cell markers. Both RL, and YWP showed activation of T cells, B cells and macrophages, compared with the normal mucosa. No decrease in TCR γ δ typeT cells was seen in YWP or RL. An increase in CD8 positive T cells was noted in YWP. The cell dencities of HLA-DR positive cells was higher in RL than in YWP. As HLA-DR positive cells can act as antigenpresenting cells, this finding may be relevant in determining the activity level of UC.
Keywords: Fine Yellowish-White Plaques in Mucosa / Ulcerative Colitis / Immunoperoxidase / Staining / Reddish Lesions
URI: http://hdl.handle.net/10069/16010
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 39, No. 4

Citable URI : http://hdl.handle.net/10069/16010

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