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Phenotype and cytokine production of Lamina Propria Mononuclear Cells from Endoscopic Biopsy Specimens in Untreated Patients with Ulcerative Colitis


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Title: Phenotype and cytokine production of Lamina Propria Mononuclear Cells from Endoscopic Biopsy Specimens in Untreated Patients with Ulcerative Colitis
Authors: Nakamuta, Koji / Makiyama, Kazuya / Senju, Masahiro / Oda, Hidetoshi
Issue Date: 15-Dec-1994
Citation: Acta medica Nagasakiensia. 1994, 39(4), p.55-60
Abstract: The phenotype of, and the production of interleukinl-β(I L-1β)and interleukin 6(IL、-6)by lamina propria mononuclear cells (LPMNC) were studied in 25 patients with ulcerative colitis (UC) (11 with untreated active disease and 14 inactive disease), and 18 control subjects. The percentage of CD4+ cells, CD20+ cells, CD3+, CD25+ cells and CD3+, HLA-DR+ cells was significantly higher in patients with active UC than in control patients, however, the percentage of CD8+ cells was significantly lower in patients with active UC than in patients with inactive UC and controls. IL-1 β was detected in nine of the ll patients(82%) with active UC but in only two of the 14 patients (14 %) with inactive UC and three of the 18 control subjects (17 %). The amount of IL-6 in patients with active UC was significantly higher than in patients with inactive UC and in controls. These results suggest that IL-1β and IL-6 mediate immune responses, and may be associated with inflammation and the etiopathogenesis of UC.
Keywords: Interleukin 1 / Interleukin / Lamina Propria / Mononuclear Cells / Ulcerative Colitis
URI: http://hdl.handle.net/10069/16012
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 39, No. 4

Citable URI : http://hdl.handle.net/10069/16012

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