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Eosinophil Cationic Protein (ECP) in Ulcerative Colitis


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Title: Eosinophil Cationic Protein (ECP) in Ulcerative Colitis
Authors: Yamasaki, Kazufumi / Makiyama, Kazuya
Issue Date: 15-Dec-1994
Citation: Acta medica Nagasakiensia. 1994, 39(4), p.67-71
Abstract: One of the eosinophil granule proteins is eosinophil cationic protein (ECP) which is basic and cytotoxic. The association of ECP in ulcerative colitis (UC) was studied by immunohistochemical method and RIA. ECP was localized in the lamina propria and the interstitium of the UC colon mucosa, showing a significant increase in distribution compared to the control. The ECP content, which was compared among the three groups according to the severity of UC classified by Matts' histopathological classification, disclosed an increasing tendency as the histological severity increased. The serum ECP level in active UC 17.68±12.25μg/L (n = 21) was significantly higher than that in inactive UC. In view of these findings, it was speculated that ECP has a role, though partial, in the damage of the colonic mucosa in UC on the basis of its biological features.
Keywords: Eosinophil cationic protein / immunohistochemical / study / redioimmunoassay / ulcerative / colti
URI: http://hdl.handle.net/10069/16014
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 39, No. 4

Citable URI : http://hdl.handle.net/10069/16014

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