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Regulation of Colonic Mucosal Blood Flow by Exogenous Ecosanoids in the Rat


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Title: Regulation of Colonic Mucosal Blood Flow by Exogenous Ecosanoids in the Rat
Authors: Yoshida, Noboru / Makiyama, Kazuya / Hoshiko, Tatsuhide
Issue Date: 15-Dec-1994
Citation: Acta medica Nagasakiensia. 1994, 39(4), p.76-81
Abstract: We measured colonic mucosal blood flow using a reflectance spectrophotometry in Wistar rats during and after continuous injection of prostaglandins (PGs: PGE1, PGE2 and PGI2), as vasodilators, and thromboxane A2 (TXA2) as a vasoconstrictor. Administration of PGs increased colonic mucosal blood volume and oxyhemoglobin saturation of the colonic mucosal tissue, representing a parameter of mucosal oxygenation. The dose used did not change arterial blood pressure. These results suggest that PGs regulate colonic mucosal hemodynamics and oxygenation, and may thus act as cytoprotective substances. On the other hand, TXA2 injection diminished colonic mucosal blood flow compared with the same dose of PGI2 injection and acted against PGI2. Our results suggest that TXA2 and PGI2 regulate colonic mucosal hemodynamics.
Keywords: Prostaglandins / inflammatory bowel disease / colonic vascularization / thromboxane A 2 / cyclic adenosine monophosphate
URI: http://hdl.handle.net/10069/16016
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 39, No. 4

Citable URI : http://hdl.handle.net/10069/16016

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