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Expression of ECM-Tenascin in Ethylnitrosourea-Induced Rat Glioma


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Title: Expression of ECM-Tenascin in Ethylnitrosourea-Induced Rat Glioma
Authors: Wu, Zhiren
Issue Date: 11-Dec-1995
Citation: Acta medica Nagasakiensia. 1995, 40(1-4), p.7-12
Abstract: Tenascin (TN) is a major extracellular matrix glycoprotein that shows a restricted distribution during fetal organogenesis and is also involved in tumor proliferation and invasion. In this study, the expression of TN and fibronectin (FN) in experimental glioma and the possible role of TN in the proliferation and infiltration of rat glioma were investigated. As a result, the tumor mesenchyme in rat gliomas of various sizes and types was found to be negative for both TN and FN. The frequency of TN-positive vessels was significantly higher in anaplastic glioma than in oligodendroglioma. Furthermore, strong TN immunoreaction was noted in the cytoplasm of anaplastic glioma cells, as was strong TN positivity in the cytoplasm and processes of reactive astrocytes. The distribusion of TN was similar to that of FN, but weak FN positivity was observed only in the cytoplasm of some tumor cells. Thus a positive correlation was observed between the frequency of TN positivity and the proliferation or anaplastic changes and malignancy of rat glioma.
Keywords: Tenascin / Extracellular matrix / Rat glioma.
URI: http://hdl.handle.net/10069/16034
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 40, No. 1-4

Citable URI : http://hdl.handle.net/10069/16034

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