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Single Lung Transplantation for the Treatment of Monocrotaline-Induced Pulmonary Hypertension in the Rat


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Title: Single Lung Transplantation for the Treatment of Monocrotaline-Induced Pulmonary Hypertension in the Rat
Authors: Yamamoto, Satoshi
Issue Date: 11-Dec-1995
Citation: Acta medica Nagasakiensia. 1995, 40(1-4), p.38-43
Abstract: Hemodynamic effects and plasma endothelin concentration following single lung transplantation for pulmonary hypertension were studied in rats with monocrotalineinduced pulmonary hypertension. Inbred male Lewis rats (weight 200-300 g) were divided into two groups. In Group 1 (control group), rats underwent syngeneic left lung transplantation. In Group 2, rats received intravenous administration of monocrotaline (80 mg/kg) and 3 weeks later underwent syngeneic left single lung transplantation. Hemodynamic evaluations were performed prior to transplantation, and one hour, 3 and 7 days after transplantation. The rats were then killed and the heart and lungs were removed to measure the ventricular weight ratio (RV/LV+S), extravascular lung water volume (ELWV : dry/wet ratio), and for histologic examination. Mean pulmonary arterial pressure (m-PAP) rapidly declined after transplantation in Group 2, from 39.3±8.7 mmHg to 18.5±3.0 mmHg 1 hour after transplantation, similar to the control (Group 1) animals, and remained stable through day 7. There was no significant difference in the mean ELWV of grafted lungs between the two groups (0.84±0.03 vs. 0.86±0.04). The mean ELWV in the native lung of Group 2 animals significantly increased on day 3 (0.86±0.02) (p<0.01), but subsequently decreased to control values by day 7 (0.83±0.02). There was no significant difference in peripheral plasma endothelin levels between groups. These data demonstrate that monocrotaline-induced rat pulmonary hypertension does not affect plasma endothelin levels, and hemodynamic improvement can be obtained via single lung transplantation. We conclude that single lung transplantation is an effective modality for the treatment of pulmonary hypertension in the rat, and may eventually be useful in patients with advanced pulmonary hypertension.
Keywords: monocrotaline / singlelung transplantation / pulmonary / hypertension endothelin
URI: http://hdl.handle.net/10069/16041
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 40, No. 1-4

Citable URI : http://hdl.handle.net/10069/16041

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