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Effect of Platelet-Activating Factor Antagonist (TCV-309) on Survival in the Canine Double Lung Transplantation Model


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Title: Effect of Platelet-Activating Factor Antagonist (TCV-309) on Survival in the Canine Double Lung Transplantation Model
Authors: Yamamoto, Satoshi / Kawahara, Katsunobu / Takahashi, Takao / Akamine, Shinji / Nagayasu, Takeshi / Yamasaki, Naoya / Tomita, Masao
Issue Date: 11-Dec-1995
Citation: Acta medica Nagasakiensia. 1995, 40(1-4), p.48-50
Abstract: Fourteen adult mongel dogs were subjected to sequential double lung transplantation. The animals were assigned randomly to three experimental groups. Four dogs served as the control group (no treatment). Four other dogs were flushed with 4°C University of Wisconsin (UW) solution (UW flush group). The remaining six dogs were treated with platelet-activating factor antagonist (TCV-309) (PAF- antagonist group). None of the animals in the control group or the UW flush group survived more than 6 hours after transplantation. In contrast, all of the dogs in the PAF- antagonist group were extubated. The mean survival in this group was 5.2 days. PAF-antagonist (TCV-309) preserved lung function and improved survival in the canine sequential double lung transplantation model.
Keywords: double lung trans plantation / platelet-activating factor (PAF)
URI: http://hdl.handle.net/10069/16043
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 40, No. 1-4

Citable URI : http://hdl.handle.net/10069/16043

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