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Endothelin Receptors in Human Myometrium and Endometrium


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タイトル: Endothelin Receptors in Human Myometrium and Endometrium
著者: Chavez, Railortega
発行日: 1996年 6月20日
引用: Acta medica Nagasakiensia. 1996, 41(1-2), p.28-34
抄録: We investigated endothelin (ET) receptors in the endometrium and the myometrium obtained from pre-menopausal 39-, 40-, and 49-year-old women, using quantitative receptor and emulsion autoradiographic methods with 125I-endothelin- 1 (125I-ET-1) [radioligand for the ET receptors], BQ-123 [specific antagonist of the ETA receptor], and sarafotoxin S6c [agonist for the ETB receptor]. The radioligand binding reached a maximum at 36 hr of incubation and a plateau was maintained for up to 72 hr. No degradation of 125I-ET-1 during incubation was observed at 72 hr. In cold-ligand saturation binding studies 125I-ET-1 bound with a single affinity to the endometrium and the myometrium. In the myometrium the ETA receptor was found to be predominantly present, and also a considerable amount of the ETB receptor was quantified. There was a significant amount of the ETA and the ETB receptor in the endometrium, and the emulsion autroradiographic technique we used revealed the ETA and the ETB receptor to be on stroma cells and glandular epithelial cells, respectively. The existence of the the ETA and the ETB receptor in the endometrium and the myometrium supports the physiological significance of ET family of peptodes in the human uterus.
キーワード: quantitative receptor autoradiography / emulsion autoradiography / endothelin / ETA receptor / ETB receptor / human uterus / endometrium / myometrium
URI: http://hdl.handle.net/10069/16047
ISSN: 00016055
資料タイプ: Departmental Bulletin Paper
原稿種類: publisher
出現コレクション:Volume 41, No. 1-2

引用URI : http://hdl.handle.net/10069/16047

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