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Diagnostic Validity of Combining HTLV-1 Serology and Immunophenotyping in Adult T-Cell Leukemia


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Title: Diagnostic Validity of Combining HTLV-1 Serology and Immunophenotyping in Adult T-Cell Leukemia
Authors: Sugahara, Kazuyuki / Tsuruda, Kazuto / Yamada, Yasuaki / Hirakata, Youichi / Atogami, Sunao / Sohda, Hisashi / Tsukazaki, Kunihiro / Tomonaga, Masao / Kamihira, Shimeru
Issue Date: Dec-1996
Citation: Acta medica Nagasakiensia. 1996, 41(3-4), p.66-70
Abstract: Adult T-cell leukemia (ATL) is heterogeneous and sometimes equivocal to other T-cell neoplasms. Detecting anti- HTLV-1 antibodies is significant for a first screening not only for HTLV-1 infection but also for the HTLV-1-related disorders of ATL and TSP/HAM. The purpose of the present study was to investigate the diagnostic validity of HTLV-1 serology in ATL. The serologic results by a gelatin particle agglutination (PA) assay were highly sensitive (100%) and specific (99.5%) for the results of polymerase chain reaction (PCR) assay in 666 healthy blood donors who live in an area endemic for the HTLV-1 virus. Of 7,536 hospitalized patients, 189 patients with ATL were serologically screened. There were 1,140 patients (15.2%) infected by chance with HTLV-1, showing specificity, sensitivity, positive predictive value (PV), and negative PV of 84.3%, 100%, 14.2%, and 100%, respectively. Since the low positive PV (14.2%) was useless, we tried combining the anti-HTLV-1 assay with the immunophenotyping necessary for the diagnosis of lymphoid neoplasms. This combination gave nearly 100% positive and negative PV, and could prove to be useful in diagnosing ATL with the probability of 98%, especially for epidemiologic studies.
Keywords: sensitivity / specificity / predictive value / ATL / HTLV-1 / anti-HTLV-1
URI: http://hdl.handle.net/10069/16067
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 41, No. 3-4

Citable URI : http://hdl.handle.net/10069/16067

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