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Hemodynamic and Catecholamine Responses to Tracheal Intubation during Inhalation of Isoflurane or Sevoflurane


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Title: Hemodynamic and Catecholamine Responses to Tracheal Intubation during Inhalation of Isoflurane or Sevoflurane
Authors: Tomiyasu, Shiro / Hara, Tetsuya / Morooka, Hiroaki / Shibata, Osamu / Sumikawa, Koji
Issue Date: Dec-1996
Citation: Acta medica Nagasakiensia. 1996, 41(3-4), p.76-79
Abstract: This study was designed to evaluate the hemodynamic and catecholamine responses to the inhalation of isoflurane and sevoflurane during anesthetic induction and to tracheal intubation in 46 adult patients who received elective surgery, Anesthesia was induced with thiamylal and vecuronium, followed by 3-min ventilation with 60% N2O (final control group ; n = 13), 60% N2O-3% isoflurane (final isoflurane group ; n = 15), or 60% N2O-4.5% sevoflurane (sevoflurane group ; n = 16) in oxygen, and the trachea was then intubated. Isoflurane inhalation caused significant increases in heart rate and plasma norepinephrine, but attenuated the pressor response to tracheal intubation. Sevoflurane inhalation caused a decrease in systolic arterial pressure with an unchanged heart rate, and attenuated the pressor and tachycardia response to tracheal intubation to a greater extent than that observed in the control and isoflurane group. Plasma norepinephrine did not show any change in the sevoflurane group. Isoflurane induction increased the sympathoadrenal activity, resulting in marked tachycardia, but attenuated the pressor response to tracheal intubation. Sevoflurane caused milder hemodynamic change during inhalation and tracheal intubation, and was accompanied by stable plasma catecholamine levels, indicating a suppression of sympathoadrenal activity.
Keywords: isoflurane / sevoflurane / anesthetic induction / catecholamine responses
URI: http://hdl.handle.net/10069/16069
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 41, No. 3-4

Citable URI : http://hdl.handle.net/10069/16069

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