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The Expression Level of Human Thymidine Phosphorylase in Urinary Tract Cancer


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Title: The Expression Level of Human Thymidine Phosphorylase in Urinary Tract Cancer
Authors: Sawase, Kenji
Issue Date: 30-Jun-1998
Citation: Acta medica Nagasakiensia. 1998, 43(1-2), p.29-32
Abstract: Human thymidine phosphorylase (dThdPase) catalyses reversible phosphorylation of thymidine to deoxyribose-1- phosphate and thymine, and is identical to Platelet-derived endothelial cell growth factor (PD-ECGF), which is an angiogenic factor purified from human platelet. In this study, we determined dThdPase expression levels in urinary tract cancer by enzyme-linked immunosorbent assay and determined whether they correlated with tumor stage and grade in bladder cancer. The mean level of dThdPase expression in cancer tissue was higher than in normal tissue in bladder cancer (41.1ツア50.7 unit/mg protein vs 17.6ツア17.8 unit/ mg protein) and in upper urinary tract cancer (52.4 ツア 53.1 unit/mg protein vs 17.6 ツア 17.8 unit/mg protein). dThdPase expression level was correlated with tumor grade and stage in bladder cancer. These data suggest that dThdPase/PDECGF is an important angiogenic factor for growth and extension of urinary tract cancer.
Keywords: human thymidine phosphorylase (dThdPase) / platelet derived endothelial cell gro w t h factor(PD-ECGF) / transitional cell carcinoma
URI: http://hdl.handle.net/10069/16101
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 43, No. 1-2

Citable URI : http://hdl.handle.net/10069/16101

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