DSpace university logo mark
詳細検索
Japanese | English 

NAOSITE : Nagasaki University's Academic Output SITE > 030 医学部 > 030 紀要 > Acta Medica Nagasakiensia > Volume 43, No. 1-2 >

Molecular Analysis of Common Types ofホア-Thalassemia Associated with(ホイ-Thalassemia in Northern Thailand


ファイル 記述 サイズフォーマット
acta43_01_06_t.pdf655.86 kBAdobe PDF本文ファイル

タイトル: Molecular Analysis of Common Types ofホア-Thalassemia Associated with(ホイ-Thalassemia in Northern Thailand
著者: Kudeken, Mika / Asato, Tsuyoshi / Tsuda, Satoshi / Nakashima, Yasutsugu / Takei, Hiroshi / Buasaengchan, Suwanna / Makonkawkeyoon, Luksana
発行日: 1998年 6月30日
引用: Acta medica Nagasakiensia. 1998, 43(1-2), p.33-37
抄録: We applied PCR strategies to detect the common types of ホア- thalassemia determinants which were associated with ホイ- thalassemia in northern Thailand. Two types of deletions in the ホア-globin gene locus;the 18 kb deletion of Southeast Asian type(-ホアSEA)and the 3.7 kb rightward deletion(-ホア3.7), and the most prevalent non-deletion mutation, Hb Constant Spring(ホアC8, TAA to CAA at the codon 141)were investigated in 22 cases of ホイ-thalassemia. Nine ホイ-thalassemia patients were found to be associated with one or two of these defective ホア-globin gene determinants and the mean hemoglobin concentration in these patients was 6.3 ツア 1.1 g/dl whereas it was 5.6ツア.0.8 g/dl in 12 ホイ-thalassemia patients without ホア- globin gene abnormalities ; the difference is statistically insignificant (p = 0.08). The level of anemia was severe in the ホイ-thalassemia patients carrying a single ホア-globin gene abnormality in the heterozygous compounds ; whereas the (ホイ-thalassemias withホア-globin gene defects in both alleles showed less severe anemia. A patient carrying the ホア ・」8 determinant in homozygous compound showed the highest hemoglobin level among these ホイ-thalassemia patients.
キーワード: a -thalassemia / R -thalassemia / polymerase chain reaction / anemia
URI: http://hdl.handle.net/10069/16102
ISSN: 00016055
資料タイプ: Departmental Bulletin Paper
原稿種類: publisher
出現コレクション:Volume 43, No. 1-2

引用URI : http://hdl.handle.net/10069/16102

このリポジトリに保管されている文献はすべて著作権により保護されています。
印刷やダウンロード等データの複製は、調査研究・教育または学習を目的とする場合に限定されます。

 

Valid XHTML 1.0! Copyright © 2006-2015 長崎大学附属図書館 - お問い合わせ Powerd by DSpace