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Molecular Analysis of Common Types ofホア-Thalassemia Associated with(ホイ-Thalassemia in Northern Thailand


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Title: Molecular Analysis of Common Types ofホア-Thalassemia Associated with(ホイ-Thalassemia in Northern Thailand
Authors: Kudeken, Mika / Asato, Tsuyoshi / Tsuda, Satoshi / Nakashima, Yasutsugu / Takei, Hiroshi / Buasaengchan, Suwanna / Makonkawkeyoon, Luksana
Issue Date: 30-Jun-1998
Citation: Acta medica Nagasakiensia. 1998, 43(1-2), p.33-37
Abstract: We applied PCR strategies to detect the common types of ホア- thalassemia determinants which were associated with ホイ- thalassemia in northern Thailand. Two types of deletions in the ホア-globin gene locus;the 18 kb deletion of Southeast Asian type(-ホアSEA)and the 3.7 kb rightward deletion(-ホア3.7), and the most prevalent non-deletion mutation, Hb Constant Spring(ホアC8, TAA to CAA at the codon 141)were investigated in 22 cases of ホイ-thalassemia. Nine ホイ-thalassemia patients were found to be associated with one or two of these defective ホア-globin gene determinants and the mean hemoglobin concentration in these patients was 6.3 ツア 1.1 g/dl whereas it was 5.6ツア.0.8 g/dl in 12 ホイ-thalassemia patients without ホア- globin gene abnormalities ; the difference is statistically insignificant (p = 0.08). The level of anemia was severe in the ホイ-thalassemia patients carrying a single ホア-globin gene abnormality in the heterozygous compounds ; whereas the (ホイ-thalassemias withホア-globin gene defects in both alleles showed less severe anemia. A patient carrying the ホア ・」8 determinant in homozygous compound showed the highest hemoglobin level among these ホイ-thalassemia patients.
Keywords: a -thalassemia / R -thalassemia / polymerase chain reaction / anemia
URI: http://hdl.handle.net/10069/16102
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 43, No. 1-2

Citable URI : http://hdl.handle.net/10069/16102

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