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Radiation Induced Cell Death in Cervical Squamous Cell Carcinoma : An Immunohistochemical and Ultrastructural Study


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Title: Radiation Induced Cell Death in Cervical Squamous Cell Carcinoma : An Immunohistochemical and Ultrastructural Study
Authors: Atari, Eio / Toda, Takayoshi / Muktafisadi, Al / Egawa, Haruhiko / Moromizat, Hidehiko / Mamadi, Touye / Kiyuna, Masaya
Issue Date: 30-Jun-1998
Citation: Acta medica Nagasakiensia. 1998, 43(1-2), p.38-43
Abstract: To study the process of cell death in cervical squamous cell carcinoma (SCC) after radiation, an ultrastructural and immunohistochemical study was performed. Paraffinembedded tissue blocks of biopsy samples pre- and postradiation stage III SCC (n = 15) were collected. Irradiation caused varying ultrastructural changes including nuclear and cytoplasmic disorganization suggesting cell necrosis. Immunohistochemically, the pre-radiation specimens showed no positive reaction for tumor necrosis factor-alpha (TNF- ホア),tumor necrosis factor-receptor(TNF-ホウ)or Fas. C-fos, p 53 and bcl-2 showed positive reactions in only a few nonirradiated specimens. All of the irradiated specimens showed a positive reaction for TNF-ホア,and variable positive reactions were observed for TNF-ホウ,Fas, p 53, c-fos and bcl-2. These results suggest that TNF-ホア,TNF-ホウ,and c-fos are responsible for radiation induced cell death in cervical SCC.
Keywords: cervical squamous cell carcinoma / cell death / TNF-alpha / TNF-receptor
URI: http://hdl.handle.net/10069/16103
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 43, No. 1-2

Citable URI : http://hdl.handle.net/10069/16103

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