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Acebutolol and Diltiazem Improves Cardiac Function and Survival of Dogs Exposed to Hyperthermia


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Title: Acebutolol and Diltiazem Improves Cardiac Function and Survival of Dogs Exposed to Hyperthermia
Authors: Fukui, Shigeru
Issue Date: 30-Jun-1998
Citation: Acta medica Nagasakiensia. 1998, 43(1-2), p.44-49
Abstract: Whole body hyperthermia against malignant neoplasms has a limited temperature because of the clinical critical thermal maximum. This study was carried out to determine whether acebutolol or diltiazem could raise a critical temperature of dogs, Twentyfour male mongrel dogs were anesthetized with a large dose of morphine (2mg/kg), and randomly divided into 3 groups. Control (group C : n = 8) received only whole body hyperthermia (WBH). Group A (n = 8) received WBH and acebutolol , and Group D (n = 8) received WBH and diltiazem. The heart rate in control dogs increased by 53% at 43ツーC from base line, whereas it increased by only 7% and 9% in the presence of acebutolol and diltiazem, respectively. Similarly, both acebutolol and diltiazem significantly improved the myocardial oxygen extraction ratio and myocardial lactate extraction ratio so well as endocardial electrocardiogram ST segment elevation. Consequently, cardiac output and LVdp/dt max at 43ツーC were significantly improved by both acebutolol and diltiazem. Seventy-five percent and 87.5% of dogs administered acebutolol and diltiazem survived respectively, whereas none of control dogs survived at 44ツーC. In conclusion, acebutolol or diltiazem improves the myocardial oxygen demand-supply balance during hyperthermia. This effect would prevent circulatory collapse, and thus might raise CTMc above 42ツーC.
Keywords: acebutolol / diltiazem / cardiac function / induced hyperthermia
URI: http://hdl.handle.net/10069/16104
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 43, No. 1-2

Citable URI : http://hdl.handle.net/10069/16104

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