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Numerical Chromosome Aberrations In A Recurrent Malignant Fibrous Histiocytoma of the Retroperitoneum


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Title: Numerical Chromosome Aberrations In A Recurrent Malignant Fibrous Histiocytoma of the Retroperitoneum
Authors: Sawai, Terumitsu / Tsuji, Takashi / Yamaguchi, Eiichiro / Nanashima, Atsushi / Jibiki, Masaaki / Yamaguchi, Hiroyuki / Yasutake, Toru / Nakagoe, Tohru / Ayabe, Hiroyoshi / Tagawa, Yutaka
Issue Date: 16-Dec-1998
Citation: Acta medica Nagasakiensia. 1998, 43(3-4), p.88-91
Abstract: Malignant fibrous histiocytoma (MFH) of the retroperitoneum is relatively rare in Japan. MFHs often recurs even if the tumor is resected completely. We describe a case with recurrent MFH of the retroperitoneum. A 49-year-old male was-admitted to our hospital for a palpable mass in the right lower abdomen. Ultrasonography and computed tomography demonstrated a solid mass with cystic compartment in the lower pole of the right kidney. The tumor was resected completely, and histological examination showed it was MFH, storiform-pleomorphic type. Thirty-three months later, a local recurrence developed and a second operation was performed. The resected tumor was 4.5 テ・3.9 テ・3.1 cm in size and histological diagnosis was recurrent MFH. We also examined the cytological characteristics of the tumor, using DNA flow cytometric quantification and fluorescence in situ hybridization (FISH) with a set of 14 chromosomespecific DNA probes. DNA contents showed a DNA diploid pattern, however, FISH analysis showed various aberrations of chromosome number such as +1, +2, +7, +8, -10, +11, +12, -16, -17, -18, and +20. These results suggested that chromosomal aberrations may reflect a higher biologic aggressiveness of recurrent MFH.
Keywords: malignant fibrous histiocytoma of the retroperitoneum / numerical chromosome aberration / fluorescence in situ hybridization
URI: http://hdl.handle.net/10069/16123
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 43, No. 3-4

Citable URI : http://hdl.handle.net/10069/16123

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