DSpace university logo mark
Advanced Search
Japanese | English 

NAOSITE : Nagasaki University's Academic Output SITE > School of Medicine > Bulletin > Acta Medica Nagasakiensia > Volume 44, No. 1-2 >

Comparison between Prolonged Administration of Oral Etoposide and UFT Combined with Intravenous Cisplatin-based Chemotherapy in Postoperative Non-small Cell Lung Cancer: a Randomized Trial


File Description SizeFormat
acta44_01_04_t.pdf475.82 kBAdobe PDFView/Open

Title: Comparison between Prolonged Administration of Oral Etoposide and UFT Combined with Intravenous Cisplatin-based Chemotherapy in Postoperative Non-small Cell Lung Cancer: a Randomized Trial
Authors: Tagawa, Yutaka / Ayabe, Hiroyoshi / Tomita, Masao / Matuzaki, Yasunori / Shibata, Koichiro / Tanaka, Koichi / Uchida, Yuzo / Ichimanda, Mitsutoshi
Issue Date: 23-Jun-1999
Citation: Acta medica Nagasakiensia. 1999, 44(1-2), p.24-28
Abstract: Oral administration of etoposide or UFT is generally used in outpatient treatment of non-small cell lung cancer (NSCLC) after surgery in Japan. We examined the effectiveness of etoposide and UFT with relation to disease-free survival, overall survival and toxicity in postoperative NSCLC patients. In this study, a total of 50 patients were randomized to receive either, 25mg/day of etoposide, on a 2 week cycle (Group I- 25 cases) or 300mg/day of UFT, continuous administration (Group II-25 cases), after a Mitomycin C, Cisplatin and Vindesine, intravenous (i.v.). Disease-free and overall survival were better in Group II with 20 complete cases than in Group I with 15 complete cases. Furthermore, Group II achieved better disease-free and overall survival rates than Group I with reference to stage IIIA and lymph node metastasis groups. There were no instances of severe toxicity in either group. Results of this study showed that prolonged oral administration of 25mg/day of etoposide is ineffective compared with oral UFT in NSCLC patients after surgical treatment. New randomized clinical trials of 50mg/day of etoposide will be necessary to determine usefulness and toxicity.
Keywords: etoposide / UFT / postoperative chemotherapy
URI: http://hdl.handle.net/10069/16129
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 44, No. 1-2

Citable URI : http://hdl.handle.net/10069/16129

All items in NAOSITE are protected by copyright, with all rights reserved.

 

Valid XHTML 1.0! Copyright © 2006-2015 Nagasaki University Library - Feedback Powerd by DSpace