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Review Article Is Biopsy Necessary if Colonoscopy is Normal in Patients With Chronic Unexplained Diarrhea?


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Title: Review Article Is Biopsy Necessary if Colonoscopy is Normal in Patients With Chronic Unexplained Diarrhea?
Authors: Murase, Kunihiko
Issue Date: 14-Jun-2000
Citation: Acta medica Nagasakiensia. 2000, 45(1-2), p.1-7
Abstract: Endoscopy and biopsy are important diagnostic tools in the evaluation of patients with chronic diarrhea and normal colonic mucosa. When colonoscopy is performed in patients with diarrhea and normal endoscopic appearance, representative sampling is important to rule out not just irritable colon but other conditions such as inflammatory bowel disease, collagenous colitis, lymphocytic colitis, eosinophilic colitis and amyloidosis. Clinically important histological lesions can be identified in a significant proportion of patients in spite of normal or nonspecific colonoscopic findings, which justifies routine mucosal biopsy in the evaluation of patients with chronic diarrhea. It is recommended that when colonoscopy is performed for the evaluation of patients with diarrhea of unknown cause and mucosa appears normal, five biopsy sites be sampled, including the cecum, transverse colon, descending colon, sigmoid colon and rectum.
URI: http://hdl.handle.net/10069/16151
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 45, No. 1-2

Citable URI : http://hdl.handle.net/10069/16151

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