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Low-Dose and Long-Term 14-Member Macrolide Therapy for Palomoplantar Pustulosis


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Title: Low-Dose and Long-Term 14-Member Macrolide Therapy for Palomoplantar Pustulosis
Authors: Matsunaga, Yoshitaka / Bae, Sangjae / Akikawa, Tomio / Kadota, Jun-Ichi / Katayama, Ichiro
Issue Date: 14-Jun-2000
Citation: Acta medica Nagasakiensia. 2000, 45(1-2), p.25-31
Abstract: We investigated the clinical efficacy of low-dose and long-term 14-member macrolide therapy for 33 patients with Palomoplantar Pustulosis (PPP) most of whom showed a poor clinical response to topical corticosteroid and/or photo chemotherapy. After 4-12 weeks treatment with oral erythromycin (EM; 600mg/day) or clarithromycin (CAM ; 200 mg/day) in combination with previously used corticosteroid ointment, clinical evaluation was made on the basis of clinical score. Results are as follows: marked improvement ; 19 patients (57.6%), moderate improvement ; 7 patients, no clinical response ; 7 patients. There was no serious side effect during the observation period. In vitro studies suggest that CAM, a 14-member macrolide, significantly down-regulated IL-8 production by keratinocytes stimulated with combination of IFNホウ and TNFホア or staphylococcal-superantigen(SEB)and IFNホウ both at protein and mRNA levels. We would like to propose that low-dose and long-term 14-member macrolide therapy is effective and an alternate therapy for PPP with poor response to ordinal dermatological therapy of which mechanism is presumable inhibition of neutrophil chemotaxisis by inhibiting IL-8 production by keratinocytes.
Keywords: palmoplantar pustulosis / macrolide / keratinocytes / IL-8
URI: http://hdl.handle.net/10069/16154
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 45, No. 1-2

Citable URI : http://hdl.handle.net/10069/16154

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