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Biological Differences Between. Polypoid and Nonpolypoid Growth Types of Colorectal Cancer


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Title: Biological Differences Between. Polypoid and Nonpolypoid Growth Types of Colorectal Cancer
Authors: Nakagoe, Tohru / Nanashima, Atsushi / Sawai, Terumitsu / Tsuji, Takashi / Ohbatake, Masayuki / Jibiki, Masaaki / Yamaguchi, Hiroyuki / Kurosaki, Nobuko / Yasutaka, Toru / Ayabe, Hiroyoshi / Miyashita, Hiroko / Arisawa, Kokichi
Issue Date: 14-Jun-2000
Citation: Acta medica Nagasakiensia. 2000, 45(1-2), p.51-59
Abstract: Background- Two distinct morphologic types of colorectal cancer have been described in recent studies: polypoid growth type (PG-type) and nonpolypoid growth type (NPG-type). Materials and Methods- We investigated possible biological and clinical differences between 37 PG-type and 156 NPGtype cancers using both univariate and multivariate analyses (logistic and Cox regression models). Results- Unlike NPG-type cancers, PG-type cancers had a high proportion of well-differentiated adenocarcinoma cells, a high likelihood of being early colorectal cancers (carcinoma in situ and cancer invades submucosa), and a low frequency of lymph node metastasis. On average, such PG-type cancers also carried a better prognosis than NPG-type cancers (P=0.01). In particular, PG-type cancer patients with stage IV tumors had a better prognosis than NPG-type cancer patients (P=0.02). In fact, after performing a Cox regression analysis, we found that colorectal cancer growth type is an independent prognostic variable, separate from histologic type or stage. Conclusions- PG-type colorectal cancer is less aggressive and has a favorable prognosis compared to NPG-type cancer.
Keywords: colorectal cancer / polypoid growth / PG-type / nonpolypoid growth / NPG-type
URI: http://hdl.handle.net/10069/16159
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 45, No. 1-2

Citable URI : http://hdl.handle.net/10069/16159

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