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Histological and Immunohistochemical Analysis of Fetal Hypoplastic Lungs: Preliminary Study


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Title: Histological and Immunohistochemical Analysis of Fetal Hypoplastic Lungs: Preliminary Study
Authors: Yoshimura, Shuichiro / Masuzaki, Hideaki / Miura, Kiyonori / Moriyama, Shingo / Fujishita, Akira / Ishimaru, Tadayuki
Issue Date: 14-Jun-2000
Citation: Acta medica Nagasakiensia. 2000, 45(1-2), p.61-66
Abstract: To investigate cellular growth and differentiation of the airway epithelium of the human fetal lung using immunohistochemistry, with a particular focus on cases of pulmonary hypoplasia. A total of 25 autopsy cases of stillbirth and early neonatal death were examined at Nagasaki University Hospital from 1986 to 1997. Using immunohistochemistry, we determined the expression of a variety of growth factors (EGFR, HGFR, GRP and SAPA) in lung tissues with or without pulmonary hypoplasia. A significant decrease in radial alveolar count was detected in hypoplastic lungs compared with normal lungs. The expressions of EGFR, HGFR and GRP in tissues from hypoplastic lungs were significantly lower than in tissues from normal lungs, but the expression of SAPA was not different between the two groups. Our results indicated that significant abnormalities of cellular growth and differentiation are present in pulmonary hypoplasia. However, lung maturation in pulmonary hypoplasia was not significantly different to that in normal lungs.
Keywords: immunohistochemistry / pulmonary hypoplasia / growth factor / GRP / surfactant apoprotei
URI: http://hdl.handle.net/10069/16160
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 45, No. 1-2

Citable URI : http://hdl.handle.net/10069/16160

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