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Signet-Ring Cell-Like Amphicrine Cell Carcinoma of the Stomach


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Title: Signet-Ring Cell-Like Amphicrine Cell Carcinoma of the Stomach
Authors: Alipov, Gabit / Nakashima, Masahiro / Ito, Masahiro / Matsuzaki, Sumihiro / Kusano, Hiroyuki / Sekine, Ichiro
Issue Date: 14-Jun-2000
Citation: Acta medica Nagasakiensia. 2000, 45(1-2), p.67-69
Abstract: A poorly differentiated adenocarcinoma containing diverse components, tubular, signet-ring cell and neuroendocrine elements, in a 79-year-old man is described. Endoscopy examination revealed a Borrmann type IV tumor in the antrum. Histologically, scattered foci of tubular and signet-ring cells and a greater number of neuroendocrine elements were observed. The tumor cells were positive for chromogranin A, neuron specific enolase (NSE) and carcinoembryonic antigen (CEA). Furthermore, about one third of the tumor cells were demonstrated as amphicrine differentiation by double staining with chromogranin A and periodic acid-Schiff (PAS). Amphicrine cell carcinomas with exocrine and endocrine differentiation in the stomach is rare and poor prognosis. The present case suggests that amphicrine cell carcinomas can occur in signet-ring cell morphogenesis, and that a multipotential stem cell is an origin of this unusual variant of neuroendocrine carcinoma.
Keywords: amphicrine cell carcinoma / stomach
URI: http://hdl.handle.net/10069/16161
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 45, No. 1-2

Citable URI : http://hdl.handle.net/10069/16161

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