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Energetic Advantage of Phosphodiesterase III Inhibitors in the Failed Heart after Global Ischemia


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Title: Energetic Advantage of Phosphodiesterase III Inhibitors in the Failed Heart after Global Ischemia
Authors: Tada, Seiichi / Eishi, Kiyoyuki / Noguchi, Manabu / Hazama, Shirou / Iwamatsu, Miyoko / Taniguchi, Shinichirou
Issue Date: 20-Jun-2001
Citation: Acta medica Nagasakiensia. 2001, 46(1-2), p.15-20
Abstract: We evaluated the ventricular mechanical effects of PhosphodiesteraseIII (PDEIII) inhibitors in the failed heart after global ischemia induced by ventricular fibrillation (VF) using the left ventricular pressure-volume relationship (PVR). In 14 anesthetized open-chest dogs, left ventricular PVR was measured using a conductance catheter. Under administration of milrinone (MIL, n=7) and olprinone (OLP, n=7), the slopes of the LV end-systolic pressure-volume (Emax), arterial end-systolic pressure-stroke volume relations (Ea), ventriculoarterial coupling (Ea/Emax) and preload recruitable stroke work (PRSW) were obtained to evaluate changes in LV performance. The duration of VF was 1 min without cardiopulmonary bypass (CPB). OLP and MIL significantly increased the Emax and PRSW values in the failed heart after VF, and there was no dose-effect relationship at MIL doses of 0.25 to 0.75ホシg/kg/min or at OLP doses of 0.1 to 0.3ホシg/kg/min. The Ea/Emax value after VF was significantly lower in the presence of OLP or MIL than in the absence of these drugs (-45.3% with OLP and -46.5% with MIL). The results indicate that in the heart after transient global ischemia, both OLP and MIL improve hemodynamic and mechanical states in terms of ventriculoarterial coupling.
Keywords: Phosphodiesterase III inhibitor / End-systolic pressure-volume relationship / preload recruitable stroke work / ventriculoarterial coupling
URI: http://hdl.handle.net/10069/16175
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 46, No. 1-2

Citable URI : http://hdl.handle.net/10069/16175

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