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Upregulation of CA 19-9 in the Mouse Kidney Following Unilateral Ureteral Obstruction

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Title: Upregulation of CA 19-9 in the Mouse Kidney Following Unilateral Ureteral Obstruction
Authors: Li, Shengwen / Nomata, Koichiro / Hayashi, Tomayoshi / Aoki, Daiyu / Kanda, Shigeru / Kanetake, Hiroshi
Issue Date: 20-Jun-2001
Citation: Acta medica Nagasakiensia. 2001, 46(1-2), p.21-25
Abstract: High serum levels of carbohydrate antigen19-9 (CA19-9) have been detected in patients with pancreatic cancer and described in several recent case reports of patients with hydronephrosis. However, the mechanism of high serum levels of CA19-9 among hydronephrosis cases remains to be elucidated. In this study, we established a mouse unilateral ureteral obstruction (UUO) model to investigate the expression of CA19-9 protein in renal tissue. To investigate the progression of hydronephrosis following UUO, MR urography and pathological analysis were performed. CA19-9 expression was examined by immunohistochemistry and western blot analysis. MR urography revealed that the grade of pelvic dilatation increased in a time dependent manner. Pathologically, both interstitial cellular infiltration and fibrosis were detected from the second to the fourteenth day after surgery in UUO mice. CA19-9 was detected in the UUO kidney after the second day. The immunoblot analysis revealed that the elevated expression of CA19-9 was demonstrated at an early stage of obstructive nephropathy. Our study shows that the ureteral obstructed kidney is dominated by cell infiltration and induced fibrosis. The selective expression of CA19-9 was detected in renal fibrous tissue. Based on these findings, the level of CA19-9 might be a good indicator for onset of renal fibrosis induced by obstruction.
Keywords: CA19-9 / hydronephrosis
URI: http://hdl.handle.net/10069/16176
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 46, No. 1-2

Citable URI : http://hdl.handle.net/10069/16176

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