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Establishment of Photoaging Mouse Model by Long-Term Repetitive UVA Irradiation


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Title: Establishment of Photoaging Mouse Model by Long-Term Repetitive UVA Irradiation
Authors: Ogawa, Fumihide / Shimizu, Kazuhiro / Jaebae, Sang / Hamasaki, Youichiro / Katayama, Ichiro
Issue Date: 20-Jun-2001
Citation: Acta medica Nagasakiensia. 2001, 46(1-2), p.39-47
Abstract: To clarify the mechanism of long-term repetitive UVA irradiation in photoaging of the skin, we evaluated albino hairless (SKH: HR1) mice by the irradiation with UVA (300-420nm ) for 12months. The output of irradiated UVA was 30J/cm2/day. Skin samples were taken from each group and examined at 0, 4, 8 and 12months. Morphologically, the structural changes of elastic fibers were observed in the dermis of irradiated group. In immunohistochemistry, tropoelastin, matrix metalloproteinase 2 (MMP2) and matrix metalloproteinase (MMP9) were expressed in the fibroblasts in the dermis of photoaged skin. The expressions of tropoelastin, MMP2 and MMP9 mRNA in cultured fibroblasts were analyzed by RT-PCR. The expression of MMP9 mRNA was increased cultured fibroblast derived from irradiated mice. These results suggest that MMP9 is an important mediator in the development of photoaged skin for one-year repetitive exposure to UVA.
Keywords: UVA / photoaging / mouse model / matrix metal loproteinase / elastin / RT-PCR
URI: http://hdl.handle.net/10069/16179
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 46, No. 1-2

Citable URI : http://hdl.handle.net/10069/16179

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