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Risk Factors for Fracture in Adult Patients with Cerebral Palsy


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Title: Risk Factors for Fracture in Adult Patients with Cerebral Palsy
Authors: Nakano, Hiroyuki / Aoyagi, Kiyoshi / Ohgi, Shohei / Akiyama, Tomitaro
Issue Date: 19-Dec-2001
Citation: Acta medica Nagasakiensia. 2001, 46(3-4), p.11-14
Abstract: Most studies on risk factors for fracture in patients with cerebral palsy have been conducted in children. We examined the relationships between age, body mass, gender, osteoporosis, osteomalacia and mobility level with history of a previous fracture in adult patients with cerebral palsy. We studied 124 institutionalized adults (52 men, age: 21-56 years, and 72 women, age: 24-47 years) with cerebral palsy. Antero-posterior radiographs of the pelvis were examined for osteoporosis and graded using the Singh index. Serum calcium, phosphate and alkaline phosphatase were measured. Osteoporosis was defined as grade 1-4 in Singh index. Osteomalacia was defined as calcium < 8.6 mg/dl, phosphate < 2.5 mg/dl or alkaline phosphatase > 220 U/l. Body mass index (BMI) was calculated from body height and weight. Medical records were examined for history of previous fractures and mobility levels (ambulatory /nonambulatory). A history of previous fracture was noted in 17 patients (6 men and 11 women). The proportion of osteoporosis in non-ambulatory patients was higher than in ambulatory patients. Multiple logistic regression analysis showed that presence of osteoporosis and mobility level (ambulation) were two factors that significantly correlated with a history of fracture. The latter did not correlate with age, BMI, gender and osteomalacia. Our findings suggest that osteoporosis is an important risk factor for fracture in adults with cerebral palsy. Since falling is also a risk factor for certain fractures, fractures seem to be more likely to occur in ambulatory patients through falling despite the low prevalence of osteoporosis.
Keywords: cerebral palsy / adult / fracture / osteoporosis / mobility
URI: http://hdl.handle.net/10069/16187
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 46, No. 3-4

Citable URI : http://hdl.handle.net/10069/16187

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