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Cellular Neurothekeoma A with an Immunohistochemical Study


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Title: Cellular Neurothekeoma A with an Immunohistochemical Study
Authors: Wen, Chunyang / Ito, Masahiro / Chen, Long-Dian / Nakayama, Toshiyuki / Nakashima, Masahiro / Tsuneda, Katsumi / Sekine, Ichiro
Issue Date: 18-Jun-2002
Citation: Acta medica Nagasakiensia. 2002, 47(1-2), p.71-73
Abstract: Cellular neurothekeoma preferentially affects women and has a predilection for the head, neck and arms of children and young adults. Cellular neurothekeoma is a wellcircumscribed tumor involving the reticular dermis and consisting of fascicles of polygonal or spindle cells with eosinophilic cytoplasma and neuroid characteristics. We describe an additional case of cellular neurothekeoma on the upper lip. Microscopically, the neoplasm had a multinodular or lobulated architecture that were partially or completely invested by a dense band of collagen and was composed of plump, spindled, and epithelioid cells arranged in solid, infiltrating nests and fascicles. Cytologically, the neoplastic cells were relatively large and contained lightly eosinophilic, finely vacuolated cytoplasm. The nuclei were round to oval with vesicular chromatin, with no atypical mitotic figures identified. Immunohistochemical examinatioa showed that the neoplastic cells were diffusely positive for vimentin and positive for NSE, but were negative for S-100 protein. Our case was a representative example of a typical cellular neurothekeoma.
Keywords: neurothekeoma / cellular neurothekeoma / Vimentin / S-100 protein
URI: http://hdl.handle.net/10069/16213
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 47, No. 1-2

Citable URI : http://hdl.handle.net/10069/16213

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